At this time, yuzu can boot some commercial Switch games to varying degrees of success, but your experience may vary between games and for different combinations of host hardware.
Click here for homebrew games you can download and test.
Nightly builds are expected to keep maximum accuracy, and therefore, cannot run many commercial titles at the moment. They are mostly useful for development purposes.
Canary builds contain code that ignores assertions, and makes games run without having implementations of service commands, GPU shaders, etc. In addition to that, Canary might also have features or fixes that have not yet been merged into Nightly.
Both builds are in constant development, so expect crashes and bugs.
Since Nightly is less compatible than Canary, we recommend using Canary builds for regular use and issue reporting.